Dr. Romain Guieze presents a case study on managing chronic lymphocytic leukemia (CLL) with a focus on treatment options, resistance mechanisms, and genetic testing for a 72-year-old patient with a history of uncontrolled hypertension and multiple relapses.
00:00 - Case Study Presentation:Â A 72-year-old patient with chronic lymphocytic leukemia (CLL) and uncontrolled hypertension.
2:39 - Resistance Mechanisms:Â Introduces resistance mechanisms to venetoclax, including BCL-2 mutations and overexpression of MCL-1.
4:51 - Treatment Guidelines:Â Reviews treatment guidelines for relapsed CLL patients, recommending BTK inhibitors for patients previously exposed to venetoclax and relapsing within three years.
6:54 - Genetic Testing:Â Emphasizes the importance of genetic testing for BTK mutations in patients previously exposed to BTK inhibitors.