Dr. Othman Al-Sawaf presented a case study on chronic lymphocytic leukemia, discussing the diagnostic workup, staging, and treatment options for a 65-year-old patient with advanced disease and low-risk CLL.
0:00 - Introduction of the Case Study: Introduces a case study on chronic lymphocytic leukemia (CLL) involving a 65-year-old female patient.
1:14 - Diagnostic Workup: Discussion on the essentials for diagnostic workup according to the NCCN guidelines, including physical examination, history taking, and laboratory tests.
2:54 - Staging and Genetic Testing: Explanation of the staging systems (Rai and Binet) and the importance of genetic testing for prognostic chromosomal alterations and mutations.
6:34 - Therapeutic Recommendations: Discussion on treatment options based on the patient's genetic profile and disease stage, including the use of BCL-2 inhibitors and BTK inhibitors.
8:56 - Treatment Recommendations: NCCN guidelines recommend fixed-duration targeted treatment for low-risk mutated IGHP CLL.