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This video covers the topic of diagnostic markers in CLL and is CME accredited for 0.25 credits (15 min).
0:00 - Introduction by Julio Delgado, head of the Oncoimmunotherapy Unit at Hospital Clinic Barcelona.
- Discussion on the critical role of diagnostic markers in differentiating CLL from other hematological malignancies.
3:00 - Explanation of the diagnosis process for CLL, including the use of a combination of markers.
- Mention of the supportive role of morphology in diagnosis.
- Discussion on the lack of specific cytogenetic or genomic aberrations for CLL diagnosis.
6:00 - Description of the current diagnosis method for CLL, which involves persistent clonal B-cell lymphocytosis and a compatible phenotype.
- Use of five compulsory markers and additional markers for fine-tuning the diagnosis.
- Emphasis on the fact that biopsies or bone marrow aspirations are not needed for CLL diagnosis.
9:00 - Overview of common genomic aberrations in CLL, which are useful for prognostic purposes.
- Mention of cytogenetics and fish as methods to identify these aberrations.
- Listing of common aberrations: XIIIq deletion, trisomy XII, XIq deletion, XVIIp deletion.